HRID1958820

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86650519

未命名化合物

结构：Cc1cc(-c2noc(-c3cccc(C=O)c3)n2)cc(C)c1OCC(O)CNC(=O)CO

HCID87208794

未命名化合物

结构：CCc1cc(C(=N)NO)cc(C)c1OC[C@@H](O)CNC(=O)CO

HCID178436630

未命名化合物

PRODUCTS

生成物

结构：CCc1cc(-c2noc(-c3cc(C=O)cc(C(C)C)c3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO

HCID86650518

未命名化合物

收率 7.8%

PROCEDURE

实验过程

The title compound (49 mg) was prepared in analogy to rac-N-(3-{4-[5-(3-formyl-phenyl)-[1,2,4]oxadiazol-3-yl]-2,6-dimethyl-phenoxy}-2-hydroxy-propyl)-2-hydroxy-acetamide, starting from 3-formyl-5-isopropyl-benzoic acid (250 mg, 1.30 mmol) and N—((S)-3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide (423 mg, 1.30 mmol); LC-MS**: tR=0.90 min; [M+1]+=481.85.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c8bea71ecc86447f927821c3006fdb95
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410151B2
来源说明: uspto-grants-2013_04

反应 SMILES

C(C1C=C(C2ON=C(C3C=C(C)C(OCC(O)CNC(=O)CO)=C(C)C=3)N=2)C=CC=1)=O.[CH:32]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([CH:43]([CH3:45])[CH3:44])[CH:42]=1)[C:37]([OH:39])=O)=[O:33].[CH2:46]([C:48]1[CH:63]=[C:62]([C:64](=[NH:67])[NH:65]O)[CH:61]=[C:60]([CH3:68])[C:49]=1[O:50][CH2:51][C@@H:52]([OH:59])[CH2:53][NH:54][C:55](=[O:58])[CH2:56][OH:57])[CH3:47]>>[CH2:46]([C:48]1[CH:63]=[C:62]([C:64]2[N:67]=[C:37]([C:36]3[CH:40]=[C:41]([CH:43]([CH3:45])[CH3:44])[CH:42]=[C:34]([CH:32]=[O:33])[CH:35]=3)[O:39][N:65]=2)[CH:61]=[C:60]([CH3:68])[C:49]=1[O:50][CH2:51][C@@H:52]([OH:59])[CH2:53][NH:54][C:55](=[O:58])[CH2:56][OH:57])[CH3:47]