Ammonia → HCID 66932543, compound

HRID 1958835Notes

Reaction equation

HRID 1958835 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([C:9]2[O:10][C:11]([C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH2:21][N:22]([CH2:24][CH3:25])[CH3:23])[CH:15]=3)=[N:12][N:13]=2)[CH:6]=[C:5]([CH3:26])[C:4]=1[OH:27])[CH3:2].[CH2:28]([C@@H:30]1[O:32][CH2:31]1)Cl.[NH3:33]>CO>[NH2:33][CH2:28][C@H:30]([OH:32])[CH2:31][O:27][C:4]1[C:5]([CH3:26])=[CH:6][C:7]([C:9]2[O:10][C:11]([C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([CH2:21][N:22]([CH2:24][CH3:25])[CH3:23])[CH:15]=3)=[N:12][N:13]=2)=[CH:8][C:3]=1[CH2:1][CH3:2]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 2734062(-)-EpichlorohydrinHCID 136352510HCID 136352510, compound

Product 1

HCID 66932543HCID 66932543, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared in analogy to Example 128 starting from the compound of Example 153 using (R)-epichlorohydrine in step a) and ammonia in methanol in step b). LC-MS: tR=0.65 min; [M+1]+=439.20.

Sources & evidence

ORD record
ord-9cdb0a637c3c4a869b4315fcec56692c
Source dataset
uspto-grants-2013_04
Patent number
US08410151B2

Reaction notes

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