1,2-Dichloroethane → HCID 66932288, compound

Participants

Reaction Steps

To a solution of (5)-1-amino-3-[2-ethyl-4-(5-{3-[(ethyl-methyl-amino)-methyl]-5-methyl-phenyl}-[1,3,4]oxadiazol-2-yl)-6-methyl-phenoxy]-propan-2-ol (214 mg, 488 μmol) in THF (5 mL), DIPEA (91 mg, 732 μmol), HOBt (66 mg, 488 μmol), EDC (94 mg, 488 μmol) and glycolic acid (37 mg, 488 μmol) is added. The mixture is stirred at rt for 1 h before DMF (2 mL) is added. Stirring is continued for 30 min. The mixture is concentrated in vacuo and then separated by prep. HPLC to give the title compound as a colourless oil (38 mg). LC-MS: tR=0.71 min; [M+1]+=497.23.

Provenance & Evidence