Ethanamine, 2,2,2-trifluoro- → HCID 25113659, compound

Participants

Reaction Steps

PS-Carbodiimide (400 mg, 123 mmol/g, Argonaut Technologies, Inc.) was added to a stirred mixture of N-[[4-[5-[3,5-bis(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenyl]carbonyl]glycine (i.e. the product of Step C, 140 mg) and 2,2,2-trifluoroethylamine (0.038 mL) in dichloromethane (3 mL) at room temperature. The mixture was stirred at room temperature overnight, then filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel eluted with ethyl acetate/hexanes to provide the title compound (115 mg), a compound of this invention, as a white solid. 1H NMR (CDCl3): δ 8.77 (d, 1H), 8.16 (d, 1H), 8.13 (s, 2H), 8.01 (s, 1H), 7.51-7.60 (m, 3H), 7.46 (t, 1H), 7.42 (d, 1H), 7.33 (d, 1H), 4.31 (d, 1H), 4.23 (d, 2H), 3.83-3.92 (m, 3H).

Provenance & Evidence