N-{5-[(tert-Butylamino)sulfonyl]-4-methyl-1,3-thiazol-2-yl)acetamide → N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide

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Reaction Steps

A solution of N-{5-[(tert-butylamino)sulfonyl]-4-methyl-1,3-thiazol-2-yl}acetamide (1.1 g) in TFA (10 ml) was stirred at room temperature for 3 d. The mixture was evaporated, redissolved in TFA (10 ml) and stirred for a further ld. On evaporation the resulting oil was azeotroped with DCM (×2) and triturated with Et2O to give the subtitle compound as a beige solid. Yield 0.7 g.

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