HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 86619883, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[2-hydroxy-1-(hydroxymethyl)ethoxy]-4-pyrimidinyl]-1-azetidinesulfonamide | HCID 11698344 | — |
| Reactant | 4,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidine | HCID 85928037 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86619883 | HCID 86619883 | — |
Reaction Steps
To a solution of 4,6-dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (the product of example 1 step (1.54 g) in THF (50 mL) was added sodium methanethiolate (0.39 g). The mixture was allowed to warm to room temperature and stirring continued for 2 h. Saturated ammonium chloride was added and the resulting mixture extracted with EtOAc. The combined organic extracts were washed with saturated aqueous sodium chloride, dried (MgSO4), filtered and evaporated to give the subtitle compound as a pale yellow solid. Yield: 1.51 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410123B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c511f3177b4d472fb5fae0f153df73a6 |
| Source note | uspto-grants-2013_04 |