HCID 85869229, compound → HCID 178433425, compound

HRID 19590Notes

Reaction equation

HRID 19590 reaction equation
[C:1]([NH:4][C:5]1[C:6]([C:13]([NH2:15])=[O:14])=[N:7][NH:8][C:9]=1[CH:10]([CH3:12])[CH3:11])(=O)[CH3:2]>[OH-].[Na+]>[CH3:2][C:1]1[N:15]=[C:13]([OH:14])[C:6]2[NH:7][N:8]=[C:9]([CH:10]([CH3:12])[CH3:11])[C:5]=2[N:4]=1

Participants

3

Reactant 1

HCID 85869229HCID 85869229, compound

Product 1

HCID 178433425HCID 178433425, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The solution of 4-acetamido-5-isopropylpyrazol-3-carboxamide XX (100 mg, 0.40 mmol) in 1 mL of 1 M sodium hydroxide was stirred at 80-90° C. for 3 hours. The product precipitated after cooling and acidifying with glacial acetic acid. Yield 98%; mp>250° C.; MS (ES+): 193.1 (100%, M+H+). 1H NMR (300 MHz; CD3OD): 1.38 d (6H, J=7.1 Hz); 2.41 s (3H); 3.02 sept (1H, J=7.1 Hz).

Workup

  1. customThe product precipitated
  2. temperatureafter cooling

Sources & evidence

ORD record
ord-20c7354559d14498ad029ed8370cce2b
Source dataset
uspto-grants-2010_06
Patent number
US07745450B2

Reaction notes

Loading…