反应详情

The solution of 4-acetamido-5-isopropylpyrazol-3-carboxamide XX (100 mg, 0.40 mmol) in 1 mL of 1 M sodium hydroxide was stirred at 80-90° C. for 3 hours. The product precipitated after cooling and acidifying with glacial acetic acid. Yield 98%; mp>250° C.; MS (ES+): 193.1 (100%, M+H+). 1H NMR (300 MHz; CD3OD): 1.38 d (6H, J=7.1 Hz); 2.41 s (3H); 3.02 sept (1H, J=7.1 Hz).

1. customThe product precipitated
2. temperatureafter cooling