4-Thiomorpholinesulfonamide, 1,1-dioxide → HCID 59558782, compound

HRID 1959003Notes

Reaction equation

HRID 1959003 reaction equation
[O:1]=[S:2]1(=[O:12])[CH2:7][CH2:6][N:5]([S:8]([NH2:11])(=[O:10])=[O:9])[CH2:4][CH2:3]1.Cl[C:14]1[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([S:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[C:25]=2[F:31])[N:15]=1>>[F:31][C:25]1[C:26]([F:30])=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][S:22][C:16]1[N:15]=[C:14]([NH:11][S:8]([N:5]2[CH2:4][CH2:3][S:2](=[O:1])(=[O:12])[CH2:7][CH2:6]2)(=[O:9])=[O:10])[CH:19]=[C:18]([O:20][CH3:21])[N:17]=1

Participants

3

Reactant 2

HCID 435818264-Thiomorpholinesulfonamide, 1,1-dioxideHCID 866198774-Chloro-2-([(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidine2×

Product 1

HCID 59558782HCID 59558782, compound

Procedure

The title compound was prepared from 1,1-dioxothiomorpholine-4-sulfonamide (0.31 g, McManus, J. M. et al, J. Med. Chem (1965) 8 766-776) and 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidine (the product of Example 35, step i) (0.25 g) according to the procedure outlined in Example 1, step iv). The crude material was purified by column chromatography using EtOAc/isohexane (1:1) as eluent. Yield: 0.48 g

Workup

  1. customThe crude material was purified by column chromatography

Sources & evidence

ORD record
ord-362f2375f40a45a7950185faa8a1b452
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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