Acetyl chloride → HCID 53628390, compound

HRID 1959028Notes

Reaction equation

HRID 1959028 reaction equation
C(Cl)(=O)C.[CH:5]([O:8][CH2:9][C@@H:10]1[CH2:14][O:13]C(C)(C)[O:11]1)([CH3:7])[CH3:6]>CO>[CH:5]([O:8][CH2:9][C@@H:10]([OH:11])[CH2:14][OH:13])([CH3:7])[CH3:6]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 53628389HCID 53628389, compound2×

Product 1

HCID 53628390HCID 53628390, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Acetyl chloride was added dropwise into a solution of MeOH (30 mL) at 0° C. with stirring for min. A solution of (4R)-4-(isopropoxymethyl)-2,2-dimethyl-1,3-dioxolane (1.7 g) (the product from step (i), in MeOH (30 mL), was added dropwise to the reaction mixture. The solution was then warmed to room temperature and stirred for 2 h. The reaction mixture was evaporated to give the subtitle compound as clear oil. Yield: 0.8 g

Workup

  1. stirringstirred for 2 h
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-75ffff0abb0d432a99d54fec15bb3e81
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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