Ammonia → HCID 53628414, compound

HRID 1959075Notes

Reaction equation

HRID 1959075 reaction equation
[F:1][C:2]1[C:37]([F:38])=[CH:36][CH:35]=[CH:34][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][N:22](C(=O)C(F)(F)F)[CH2:23]3)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH:9]=[C:8]([O:32][CH3:33])[N:7]=1.N>CO>[F:1][C:2]1[C:37]([F:38])=[CH:36][CH:35]=[CH:34][C:3]=1[CH2:4][S:5][C:6]1[N:11]=[C:10]([NH:12][S:13]([C:16]2[CH:25]=[C:24]3[C:19]([CH2:20][CH2:21][NH:22][CH2:23]3)=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH:9]=[C:8]([O:32][CH3:33])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86619893HCID 86619893, compound

Product 1

HCID 53628414HCID 53628414, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl) 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (0.805 g) was added to a solution of 7N NH3 in MeOH (20 ml), sealed and stirred at room temperature for 2 h. The reaction was reduced in vacuo and the resulting residue purified by prep HPLC to give the title compound as a white solid. Yield: 70 mg

Workup

  1. customsealed
  2. customthe resulting residue purified by prep HPLC

Sources & evidence

ORD record
ord-774ed37916544d1eb537b256da771ff0
Source dataset
uspto-grants-2013_04
Patent number
US08410123B2

Reaction notes

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