Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 59442983, compound

Participants

Reaction Steps

Under argon atmosphere, a mixture of (4-chloro-2-hydroxyphenyl)(4-fluorophenyl)methanone (1.00 and methyl(triphenylphosphoranylidene)acetate (3.00 g) in toluene (15 mL) was heated under reflux for 15 hours. After cooling, the reaction solution was poured into a saturated aqueous solution of ammonium chloride and the mixture was extracted with ethyl acetate. The organic layer was washed successively with a saturated aqueous solution of sodium bicarbonate and brine, dried over sodium sulfate and concentrated in vacuo. The resultant residue was purified by column chromatography on silica gel (Solvent: n-hexane/ethyl acetate=95/5 to 85/15) and the product was triturated in n-hexane-diisopropyl ether to give the titled compound (0.54 g) as a pale yellow powder.

Provenance & Evidence