1,4-Dioxane hydrochloride → HCID 59443066, compound

HRID 1959120Notes

Reaction equation

HRID 1959120 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([NH:18]C(=O)OC(C)(C)C)=[CH:15][CH:16]=3)[O:11][C:10]([CH3:27])([CH3:26])[C:9]=2[CH3:28])=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([NH2:18])=[CH:15][CH:16]=3)[O:11][C:10]([CH3:27])([CH3:26])[C:9]=2[CH3:28])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59443087HCID 59443087, compound

Product 1

HCID 59443066HCID 59443066, compound

Procedure

The compound obtained in (4) described above (126 mg) and 4N hydrochloric acid-dioxane solution (3 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound (66 mg) as a pale brown viscous oil.

Sources & evidence

ORD record
ord-c1ba3a0cb0ef4ea693cd8ff941077f30
Source dataset
uspto-grants-2013_04
Patent number
US08410166B2

Reaction notes

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