1,4-Dioxane hydrochloride → HCID 59442934, compound

HRID 1959124Notes

Reaction equation

HRID 1959124 reaction equation
[F:1][C:2]1[C:3]([CH3:28])([CH3:27])[O:4][C:5]2[C:10]([C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=[CH:9][CH:8]=[C:7]([NH:19]C(=O)OC(C)(C)C)[CH:6]=2.Cl.O1CCOCC1>>[F:1][C:2]1[C:3]([CH3:28])([CH3:27])[O:4][C:5]2[C:10]([C:11]=1[C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)=[CH:9][CH:8]=[C:7]([NH2:19])[CH:6]=2

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59443050HCID 59443050, compound

Product 1

HCID 59442934HCID 59442934, compound

Procedure

The compound obtained in (6) described above (157 mg) and 4N hydrochloric acid-dioxane solution (4 mL) were treated in the same manner as Reference Example 5(5) to give the titled compound (108 mg) as a pale yellow viscous oil.

Sources & evidence

ORD record
ord-395b6ca30fb94e9e8ff11f9be57147ed
Source dataset
uspto-grants-2013_04
Patent number
US08410166B2

Reaction notes

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