tert-Butyl carbamate → tert-butyl [3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen-7-yl]carbamate

HRID 1959130Notes

Reaction equation

HRID 1959130 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[C:7]([CH:14]3[CH2:16][CH2:15]3)[C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][CH:3]=1.[C:24](=[O:31])([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[NH2:25]>>[CH:14]1([C:7]2[C:8]([CH3:13])([CH3:12])[O:9][C:10]3[C:5]([C:6]=2[C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:4][CH:3]=[C:2]([NH:25][C:24](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:11]=3)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 77922tert-Butyl carbamateHCID 594430267-chloro-3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen

Product 1

HCID 59443016tert-butyl [3-cyclopropyl-4-(4-fluorophenyl)-2,2-dimethyl-2H-chromen-7-yl]carbamate

Procedure

The compound obtained in (1) described above (112 mg) and tert-butyl carbamate (240 mg) were treated in the same manner as Reference Example 5(4) to give the titled compound (117 mg) as a pale brown powder.

Sources & evidence

ORD record
ord-3440e8c0bc8d40caa3c6ab7ed56edf5a
Source dataset
uspto-grants-2013_04
Patent number
US08410166B2

Reaction notes

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