Dichloromethane → HCID 68485519, compound

Participants

Reaction Conditions

Reaction Steps

4-Fluorobenzoyl chloride (7.76 mL) was added to a solution of 3,5-dimethoxytoluene (10 g) in dichloromethane (200 mL) and aluminum chloride (13.7 g) was added to the solution cooled at −40° C. and the mixture was stirred at the same temperature for 30 minutes. The reaction mixture was poured into ice water and the mixture was extracted with dichloromethane (200 mL×3). The combined organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (Solvent; petroleum ether/ethyl acetate=50/1) to give the titled compound (7.5 g) as a yellow powder.

Provenance & Evidence