Tetrabutylammonium Fluoride → HCID 59443008, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in (2) described above (2 g) in tetrahydrofuran (20 mL) was added 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (10 mL) under stirring at 0° C. and the mixture was stirred at the same temperature for 3 hours. The reaction solution was diluted with an aqueous solution of ammonium chloride (50 mL) and extracted with ethyl acetate (30 mL×3). The combined organic layer was dried over sodium sulfate and concentrated in vacuo to give the titled compound (1.5 g) as a brown powder, which was used in the next step without further purification.

Provenance & Evidence