反应详情

5,7-Dichloro-3-isopropylpyrazolo[4,3-d]pyrimidine (1.015 mmol; 234.6 mg), 1 mL benzylamine and n-butanol (2 mL) were stirred at 65° C. for 4 hours. The reaction mixture was evaporated to dryness in vacuo. The residue was chromatographed on silica gel eluted with the following solvent system: CHCl3/MeOH (99/1), to give 7-benzylamino-5-chloro-3-isopropylpyrazolo[4,3-d]pyrimidine. Yield 96%; MS (ES+): 302.3 (100%, M+H+), 304.3 (32%, M+H+). 1H NMR (CDCl3; 300 MHz): 1.37 d (6H, J=7.1 Hz); 3.39 sept (1H, J=7.1 Hz), 6.72 s (1H), 4.82 s (2H), 7.28 m (5H).

1. customThe reaction mixture was evaporated to dryness in vacuo
2. customThe residue was chromatographed on silica gel
3. washeluted with the following solvent system