6-Methyl-2-oxo-4-propyl-1,2-dihydropyridine-3-carbonitrile → 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate

Participants

Reaction Steps

To a solution of 6-methyl-2-oxo-4-propyl-1,2-dihydropyridine-3-carbonitrile (1.3 g, 7.38 mmol) in methanol and aq. ammonia solution (50 mL, 9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (1.2 g, 92%).

Provenance & Evidence