HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Cyano-4,6-dimethyl-2-hydroxypyridine | HCID 69856 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 737752 | 72% |
Reaction Steps
To a stirred suspension of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (5 g, 33.78 mmol) in AcOH (25 mL) was dropwise added bromine (2.5 mL) at rt. Resulting solution was stirred for 1 h. Solvent was removed under reduced pressure. Obtained solid was recrystallised in hot EtOH and H2O to give the title compound as a white solid (5.5 g, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410088B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-a99087e896f440a0b03e6d46ba18f839 |
| Source note | uspto-grants-2013_04 |