反应详情

温度

100 °C

Polyphosphonic acid (25 mL of 84% w/v, 256.1 mmol) was heated to 100° C. and treated with 3-amino-N′-benzoyl-6-bromo-pyrazine-2-carbohydrazide (6.82 g, 20.29 mmol) in portions. Analysis after 1 hour showed SM remaining therefore further polyphosphonic acid was added (25 mL of 84% w/v, 256.1 mmol). The reaction was heated for a total of 3 hours and then allowed to cool. Water was added and the mixture allowed to stir to obtain a precipitate which was filtered and dried under vacuum (5.02 g, 78% Yield). MS (ES+) 317.86

1. additionfurther polyphosphonic acid was added (25 mL of 84% w/v, 256.1 mmol)
2. temperatureThe reaction was heated for a total of 3 hours
3. temperatureto cool
4. customto obtain a precipitate which
5. filtrationwas filtered
6. customdried under vacuum (5.02 g, 78% Yield)