HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-(1H-Imidazol-1-yl)-2-methylquinolin-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 4-Chloro-8-hydroxy-2-methylquinoline | HCID 12219722 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(1H-Imidazol-1-yl)-2-methylquinolin-8-ol | HCID 18404236 | — |
Reaction Steps
A mixture of 4-chloro-2-methyl-quinolin-8-ol (2.0 g, 10 mmol) and imidazole (3.53 g, 51.8 mmol) in dioxane (20 mL) was heated to reflux for 28 h. The solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel (elution with DCM/methanol 10:1) to give the title compound. MS (m/z): 226.3 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-653e6d7c75f54932bd69a4ffcd6a882c |
| Source note | uspto-grants-2013_04 |