Triethylamine → HCID 67077953, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,5-dichloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine (400 mg, 1.533 mmol), triethylamine (278 μL, 1.993 mmol), (1,1′-bis(diphenylphosphino)ferrocene)-dichloropalladium(II)•DCM (PdCl2(dppf)2•DCM, 63 mg, 0.077 mmol) and 4 Å molecular sieves (600 mg) in MeOH (10 mL) was stirred at 120° C. for 5 h under an atmosphere of carbon monoxide (15 bar). The reaction was filtered and the solvent was removed in vacuo. The residue was purified by flash chromatography on silica gel (elution with mixtures of hexane/EA) to give the title compound. MS (m/z): 286.0 [M+H+].

Provenance & Evidence