HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → 5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | HCID 44190473 | HCID 44190473 | — |
| Reactant | 1-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone | HCID 67077143 | — |
| Product | 5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine-3-carbaldehyde | HCID 44190474 | — |
Reaction Steps
Reaction of 3-bromo-5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine (0.36 g, 1.0 mmol) with formic acid ethyl ester (1.6 mL, 20 mmol) according to the synthesis of 1-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-2-methoxy-ethanone yielded the title compound. MS (m/z): 256.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ccf5c36811fc4512a34fc67d05e9dd45 |
| Source note | uspto-grants-2013_04 |