(3,5-Dichloropyridin-4-yl)methanol → HCID 86645359, compound

HRID 1959570Notes

Reaction equation

HRID 1959570 reaction equation
ClC1C=NC=C(Cl)C=1CO.[Cl:11][C:12]1[C:17]([CH:18]=[O:19])=[C:16]([S:20][C:21]2[S:22][CH:23]=[CH:24][N:25]=2)[CH:15]=[CH:14][N:13]=1>>[Cl:11][C:12]1[C:17]([CH2:18][OH:19])=[C:16]([S:20][C:21]2[S:22][CH:23]=[CH:24][N:25]=2)[CH:15]=[CH:14][N:13]=1

Participants

3

Reactant 2

HCID 17855219(3,5-Dichloropyridin-4-yl)methanolHCID 86645357HCID 86645357, compound

Product 1

HCID 86645359HCID 86645359, compound

Procedure

The aldehyde group in 2-chloro-4-(thiazol-2-ylsulfanyl)-pyridine-3-carbaldehyde was reduced as described for the synthesis of (3,5-dichloro-pyridin-4-yl)-methanol to give the title compound which was used in the following step without further purification. MS (m/z): 259.2 [M+H+].

Sources & evidence

ORD record
ord-d0dde40ffed4452989886ed63d253ea8
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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