(3,5-Dichloropyridin-4-yl)methanol → HCID 67077521, compound

HRID 1959580Notes

Reaction equation

HRID 1959580 reaction equation
ClC1C=NC=C(Cl)C=1CO.[Cl:11][C:12]1[C:13]([CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:32]=2[N:31]=[C:30]([CH3:33])[CH:29]=[C:28]3[C:34]2[N:35]([CH3:39])[N:36]=[CH:37][CH:38]=2)=[C:14]([C:18](=[O:20])[CH3:19])[CH:15]=[N:16][CH:17]=1>>[Cl:11][C:12]1[C:13]([CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:32]=2[N:31]=[C:30]([CH3:33])[CH:29]=[C:28]3[C:34]2[N:35]([CH3:39])[N:36]=[CH:37][CH:38]=2)=[C:14]([CH:18]([OH:20])[CH3:19])[CH:15]=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 17855219(3,5-Dichloropyridin-4-yl)methanolHCID 59484227HCID 59484227, compound

Product 1

HCID 67077521HCID 67077521, compound

Procedure

Reduction of the ketone in 1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-yl)-quinolin-8-yloxymethyl]-pyridin-3-yl}-ethanone according to the synthesis of (3,5-dichloro-pyridin-4-yl)-methanol yielded the title compound. MS (m/z): 409.0 [M+H+].

Sources & evidence

ORD record
ord-a4323a5fa5654b299685da6317ed8703
Source dataset
uspto-grants-2013_04
Patent number
US08410134B2

Reaction notes

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