HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,5-Dichloro-4-(chloromethyl)-2-pyridinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Amino-3,5-dichloro-pyridin-4-yl)-methanol | HCID 18511693 | — |
| Reactant | 3,5-Dichloro-4-(chloromethyl)pyridine | HCID 22626853 | — |
| Product | 3,5-Dichloro-4-(chloromethyl)-2-pyridinamine | HCID 18752883 | — |
Reaction Steps
(2-Amino-3,5-dichloro-pyridin-4-yl)-methanol (7 mg, 0.036 mmol) was chlorinated with SOCl2 according to the synthesis of 3,5-dichloro-4-chloromethyl-pyridine. The resulting title compound was used for the next reaction without purification. MS (m/z): 211.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-8882ff6dfb5947f094121c5ea4079373 |
| Source note | uspto-grants-2013_04 |