HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Dimethyl-carbamic acid 6-amino-5-chloro-4-chloromethyl-pyridin-3-ylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-Dichloro-4-(chloromethyl)pyridine | HCID 22626853 | — |
| Reactant | Dimethyl-carbamic acid 6-amino-5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl ester | HCID 67078166 | — |
| Product | Dimethyl-carbamic acid 6-amino-5-chloro-4-chloromethyl-pyridin-3-ylmethyl ester | HCID 67077397 | — |
Reaction Steps
Dimethyl-carbamic acid 6-amino-5-chloro-4-hydroxymethyl-pyridin-3-ylmethyl ester (18.5 mg, 0.071 mmol) was chlorinated with SOCl2 according to the synthesis of 3,5-dichloro-4-chloromethyl-pyridine. The resulting title compound was used for the next reaction without purification. MS (m/z): 278.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-b7e9cd25355c4625b7f4be63c9b2c79c |
| Source note | uspto-grants-2013_04 |