1-(3-Chloromethyl-4-methyl-pyridin-2-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one → 1-(4-Methyl-3-{2-methyl-4-[4-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-quinolin-8-yloxymethyl}-pyridin-2-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one

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Reaction Steps

2-Methyl-4-[4-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-quinolin-8-ol and 1-(3-chloromethyl-4-methyl-pyridin-2-ylmethyl)-3-trifluoromethyl-1H-pyridin-2-one were coupled according to the procedure described for the synthesis of 8-(3,5-dichloro-pyridin-4-ylmethoxy)-4-imidazol-1-yl-2-methyl-quinoline to give the title compound which was used in the next step without purification.

Provenance & Evidence