HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Pyrazol-4-ol → 2-Methyl-4-[1-(tetrahydro-pyran-2-yl)-4-(tetrahydro-pyran-2-yloxy)-1H-pyrazol-3-yl]-quinolin-8-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Pyrazol-4-ol | HCID 119218 | — |
| Reactant | HCID 44190473 | HCID 44190473 | — |
| Reactant | 4-Bromo-2-methyl-quinolin-8-ol | HCID 67077159 | — |
| Reactant | 2-Methyl-4-(1-methyl-1H-imidazol-2-yl)-quinolin-8-ol | HCID 135950306 | — |
| Product | 2-Methyl-4-[1-(tetrahydro-pyran-2-yl)-4-(tetrahydro-pyran-2-yloxy)-1H-pyrazol-3-yl]-quinolin-8-ol | HCID 136346376 | — |
Reaction Steps
THP protection of 1H-Pyrazol-4-ol (420 mg. 2.06 mmol) according to the synthesis of 3-bromo-5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridine subsequent coupling with 4-bromo-2-methyl-quinolin-8-ol according to the synthesis of 2-methyl-4-(1-methyl-1H-imidazol-2-yl)-quinolin-8-ol and flash chromatographic purification yielded the title compound. MS (m/z): 410.0 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-a8b4ad7935a7471e87d6b559a8a738a9 |
| Source note | uspto-grants-2013_04 |