HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-(tetrahydro-pyran-2-yloxymethyl)-2-vinyl-pyridine → HCID 67077239, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-(tetrahydro-pyran-2-yloxymethyl)-2-vinyl-pyridine | HCID 44190585 | — |
| Reactant | [4-Methyl-3-(tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol | HCID 44191034 | — |
| Reactant | HCID 86645362 | HCID 86645362 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | HCID 67077239 | HCID 67077239 | — |
Reaction Steps
Pd catalyzed vinylation of 2,4-dichloro-3-(tetrahydro-pyran-2-yloxymethyl)-pyridine (1.71 g. 6.52 mmol) according to the synthesis of 4-methyl-3-(tetrahydro-pyran-2-yloxymethyl)-2-vinyl-pyridine subsequent ozonolysis and reduction according to the synthesis of [4-methyl-3-(tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol and flash chromatographic purification yielded the title compound. MS (m/z): 257.8 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410134B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-fc1a5bcb582240d8ae7531fe511d11ba |
| Source note | uspto-grants-2013_04 |