HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 1-(Quinolin-6-yl)cyclopropanecarbohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 1-(quinolin-6-yl)cyclopropanecarboxylate | HCID 58190477 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Quinolin-6-yl)cyclopropanecarbohydrazide | HCID 66927158 | 100% |
Reaction Steps
A solution of methyl 1-(quinolin-6-yl)cyclopropanecarboxylate (513 mg, 2.26 mmol) and hydrazine monohydrate (3.39 g, 67.7 mmol) in 5 mL of methanol was heated at reflux overnight. After cooling, solvent was removed in vacuo to afford the title compound (513 mg, 100%). LCMS (method A): [MH]+=228, tR=2.88 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410264B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-7242ce673159472ab3585b6261d29ae8 |
| Source note | uspto-grants-2013_04 |