反应详情

温度

140 °C

A sealed tube was charged with 1-(quinolin-6-yl)cyclopropanecarbohydrazide (513 mg, 2.26 mmol), 3,6-dichloro-pyridazine (437 mg, 2.93 mmol) and 5 mL of n-butanol. The mixture was heated at 140° C. for 12 h. After cooling, solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel eluting with EtOAc/methanol gradient to afford the title compound (196 mg, 41%). LCMS (method A): [MH]+=322, tR=4.38 min.

1. temperatureAfter cooling
2. customsolvent was removed in vacuo
3. customthe residue was purified by flash chromatography on silica gel eluting with EtOAc/methanol gradient