Ammonia methanol → HCID 46940875, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 8-(3-fluoro-4-hydroxyphenyl)-1,6-naphthyridine-2-carboxylate (100 mg, 0.32 mmol) synthesized in Example 1 (1a) was dissolved in a 7M ammonia-methanol solution (10 mL), followed by stirring while heating at 80° C. for three hours. After cooling the resulting reaction liquid to room temperature, a precipitated solid was collected by filtration to give the desired title compound (51 mg, yield 56%).

Provenance & Evidence