1,4-Dioxane hydrochloride → HCID 66730517, compound

Participants

Reaction Steps

Tert-butyl 4-{2-[4-(2-carbamoyl-1,6-naphthyridin-8-yl)-2-fluorophenoxy]ethoxy}benzoate (174 mg, 0.346 mmol) was synthesized from ethyl 8-(3-fluoro-4-hydroxyphenyl)-1,6-naphthyridine-2-carboxylate synthesized in Example 1 (1a) and tert-butyl 4-(2-hydroxyethoxy)benzoate synthesized in Reference Example 9 by the same methods as in Example 2 (2a) and (2b), and then dissolved in 1,4-dioxane (1.0 mL). To the resulting mixture, a 4M HCl/1,4-dioxane solution (8.0 mL) was added at 0° C., followed by stirring overnight.

Provenance & Evidence