4-Chlorophenylboronic acid → 2-(Trimethylsilyl)ethyl 4-(4-chlorophenyl)isoquinoline-6-carboxylate

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Reaction Steps

From 2-(trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate (6.00 g, 14.2 mmol) and 4-chlorophenylboronic acid (3.30 g, 30.0 mmol), 2-(trimethylsilyl)ethyl 4-(4-chlorophenyl)isoquinoline-6-carboxylate (3.90 g, yield 71%) was obtained by the same method as in Example 8 (8a). Further, using this compound (3.90 g, 9.9 mmol), the desired title compound (1.96 g, yield 70%) was obtained by the same method as in Example 4 (4b).

Provenance & Evidence