1,4-Dioxane hydrochloride → HCID 66730472, compound

Participants

Reaction Steps

Into methanol (250 ml), 4-(4-chlorophenyl)isoquinoline-6-carboxamide (1.9 g, 6.7 mmol) synthesized in Example 7 (7a) was dissolved, to which a 4M hydrochloric acid-dioxane solution (5 ml, 20 mmol) was added. After stirring at room temperature for 30 minutes, the resulting mixture was concentrated under reduced pressure. The resulting product was subjected to azeotropic distillation with diethyl ether, followed by recrystallization from methanol-diethyl ether to give the desired title compound (2 g, yield 93%).

Provenance & Evidence