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p-Formylphenylboric acid → 2-(Trimethylsilyl)ethyl 4-(4-formylphenyl)isoquinoline-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Formylphenylboric acid | HCID 21940015 | — |
| 反応物 | 2-(Trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate | HCID 58495760 | — |
| 生成物 | 2-(Trimethylsilyl)ethyl 4-(4-formylphenyl)isoquinoline-6-carboxylate | HCID 86661966 | 79.7% |
反応手順
Using 2-(trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate (600 mg, 1.42 mmol) and 4-formylphenylboric acid (320 mg, 2.14 mmol), the desired title compound (427 mg, yield 79%) was obtained by the same method as in Example 8 (8a).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08410273B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-0fadfcfdb6754866851a45ba02dd125c |
| 出典メモ | uspto-grants-2013_04 |