Methyl Isocyanate → HCID 67030708, compound

Participants

Reaction Steps

Following general method 4, employing 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester and methyl isocyanate, afforded the title compound as a white solid (194 mg, 74%); LCMS (method B): RT=3.38 min, M+H+=306; 1H NMR (CDCl3, 300 MHz): 8.42 (s, 1H), 7.64 (d, J=2.7 Hz, 1H), 7.46 (d, J=2.7 Hz, 1H), 7.39 (dt, J=8.2, 6.2 Hz, 1H), 7.24-7.20 (m, 1H), 7.15 (dt, J=9.9, 2.3 Hz, 1H), 6.99 (tdd, J=8.3, 2.4, 0.9 Hz, 1H), 4.71-4.65 (m, 1H), 4.31 (q, J=7.1 Hz, 2H), 2.90 (d, J=4.9 Hz, 3H), 1.37 (t, J=7.1 Hz, 3H).

Provenance & Evidence