Ethyl isocyanate → HCID 67031346, compound

Participants

Reaction Steps

Following general method 4, employing 3-amino-1-(3-fluorophenyl)-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester and ethyl isocyanate, afforded the title compound as a cream solid (0.192 g, 73%); LCMS (method B): RT=3.61 min, M+H+=320; 1H NMR (CDCl3, 300 MHz): 8.41 (s, 1H), 7.62 (d, J=2.7 Hz, 1H), 7.44 (d, J=2.7 Hz, 1H), 7.38 (dt, J=8.2, 6.2 Hz, 1H), 7.21 (dd, J=8.2, 2.4 Hz, 1H), 7.14 (dt, J=9.9, 2.4 Hz, 1H), 6.98 (td, J=8.2, 2.4 Hz, 1H), 4.73 (s, 1H), 4.31 (q, J=7.1 Hz, 2H), 3.35-3.26 (m, 2H), 1.37 (t, J=7.1 Hz, 3H), 1.21 (t, J=7.1 Hz, 3H).

Provenance & Evidence