HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylamine → HCID 67030773, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 67030762 | HCID 67030762 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67030773 | HCID 67030773 | 65% |
Reaction Steps
Following general method 6, employing (S)-3-{[1-(3-fluorophenyl)-4-ureido-1H-pyrrole-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester and propylamine, afforded the crude desired product. Column chromatography (silica, 12 g column, ISCO, 0-50% ethyl acetate in DCM) afforded the title compound as glass (100 mg, 65%); LCMS (method B): RT=3.89 min, M+H+=488.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410279B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-96f31d2530e34dd1b106c8e4f27c0c96 |
| Source note | uspto-grants-2013_04 |