HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 67030537, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | HCID 67030762 | HCID 67030762 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67030537 | HCID 67030537 | 60% |
Reaction Steps
Following general method 6, employing (S)-3-{[1-(3-fluorophenyl)-4-ureido-1H-pyrrole-3-carbonyl]amino}-piperidine-1-carboxylic acid tert-butyl ester and 3-amino-propan-1-ol, afforded the crude desired product. Column chromatography (silica, 12 g column, ISCO, 0-100% ethyl acetate in DCM) afforded the title compound as a glass (70 mg, 60%); LCMS (method B): RT=3.37 min, M+H+=504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410279B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-5fcc82b852d44960b979f9ade2e119b1 |
| Source note | uspto-grants-2013_04 |