Ethyl Acetate → HCID 86653566, compound

Participants

Reaction Steps

Following general method 7, employing (S)-3-{[1-(3-fluorophenyl)-4-ureido-1H-pyrrole-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester and 2-fluoroethylamine hydrochloride, afforded the crude desired product (Note: 0.34 mmol of anhydrous sodium acetate was added to the reaction mixture to neutralise the amine). Column chromatography (silica, 12 g column, ISCO, 0-100% ethyl acetate in DCM) afforded the title compound as a glass (80 mg, 95%). LCMS (method B): RT=3.68 min, M+H+=492.

Provenance & Evidence