HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 86653567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2,2-Difluoroethanamine | HCID 136274 | — |
| Reactant | HCID 67030762 | HCID 67030762 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86653567 | HCID 86653567 | 57% |
Reaction Steps
Following general method 7, employing (S)-3-{[1-(3-fluorophenyl)-4-ureido-1H-pyrrole-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester and 2,2-difluoroethylamine, afforded the crude desired product. Column chromatography (silica, 12 g column, ISCO, 0-50% ethyl acetate in DCM) afforded the title compound as a glass (100 mg, 57%). LCMS (method B): RT=3.81 min, M+H+=510.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410279B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-9d39c3b273894189b892d160598648d8 |
| Source note | uspto-grants-2013_04 |