HRID1960093

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID671214

未命名化合物

结构：COC(=O)N[C@@H](Cc1ccccc1Br)C(=O)NCCCC[C@@H](COP(=O)(O)O)N(CC(C)C)S(=O)(=O)c1ccc(N)cc1

HCID24999240

未命名化合物

PRODUCTS

生成物

结构：COC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)NCCCC[C@@H](COP(=O)(O)O)N(CC(C)C)S(=O)(=O)c1ccc(N)cc1

HCID68474076

未命名化合物

收率 28%

PROCEDURE

实验过程

This derivative was synthesized using the procedure described for the preparation of (1S,5S)-[1-{5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-phosphonooxy-hexylcarbamoyl}-2-(2-bromo-phenyl)-ethyl]-carbamic acid methyl ester (example 4, steps A and B) using L-4-bromophenylalanine (Peptech Corp.) instead of L-2-bromophenylalanine. The desired material was obtained in 28% yield (25 mg)

WORKUP

后处理

customThis derivative was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67c31c17cfbb42e1b758f838f0a5ac55
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08410300B2
来源说明: uspto-grants-2013_04

反应 SMILES

[CH3:1][O:2][C:3](=[O:43])[NH:4][C@H:5]([C:14](=[O:42])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][C@H:20]([N:27]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=1)(=[O:34])=[O:33])[CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:21][O:22][P:23]([OH:26])([OH:25])=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1Br.C1C(C[C@H](N)C(O)=O)=CC=C([Br:56])C=1>>[CH3:1][O:2][C:3](=[O:43])[NH:4][C@H:5]([C:14](=[O:42])[NH:15][CH2:16][CH2:17][CH2:18][CH2:19][C@H:20]([N:27]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=1)(=[O:33])=[O:34])[CH2:28][CH:29]([CH3:30])[CH3:31])[CH2:21][O:22][P:23]([OH:26])([OH:25])=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:56])=[CH:9][CH:8]=1