HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-methyl-5-nitrobenzoate → Methyl 5-Amino-2-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-methyl-5-nitrobenzoate | HCID 4377758 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5-Amino-2-methylbenzoate | HCID 15049977 | — |
Reaction Steps
To a solution of methyl 2-methyl-5-nitrobenzoate (60 g, 307 mmol) in MeOH (600 mL) was added Pd (10 wt % on carbon) (1.6 g). The reaction was shaken under hydrogen (30-50 psi) for 1 h, filtered through a celite pad and concentrated to afford the desired product as a red paste, which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410284B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-4aeb9cf4a3f240afa5a5af979f67f1d2 |
| Source note | uspto-grants-2013_04 |