Triphenyl phosphite → HCID 67448110, compound

Participants

Reaction Steps

To a microwave vial containing a solution of Intermediate 11-1 (which was prepared from 5-chloro-4-iodo-1,2-phenylenediamine (Intermediate 1-6 of Example 1) and 4-biphenylboronic acid following the procedures of Step 9 in Example 1) (500 mg, 1.7 mmol) in pyridine 8 mL was added 3-bromo-phenyl acetic acid (365 mg, 1.7 mmol), followed by triphenyl phosphite (0.58 mL, 2.2 mmol). The reaction was run in a microwave reactor at 220° C. for 10 min. The solvent was partially removed in vacuo, then diluted with EtOAc (75 mL) and washed three times with 50 mL portions of saturated aqueous ammonium chloride. The combined organic layers were dried (MgSO4), filtered, concentrated in vacuo, and then purified by chromatography over silica (eluting with EtOAc/Hexanes=1/1) to give the title compound 14-1 as a tan solid.

Provenance & Evidence