Hexamethyldisilazane → HCID 58482538, compound

Participants

Reaction Steps

To a solution of compound 14-3 (56 mg, 0.098 mmol) in 2 mL of CH2Cl2 was added hexamethyldisilizane (0.3 mL), followed by bromo trimethylsilane (0.13 mL, 0.98 mmol). The reaction was allowed to stir for 18 h at ambient temperature. The organic solvent was removed in vacuo, followed by the addition of H2O (2 mL). The crude product was sonicated and yielded a yellow suspension. The product was collected by vacuum filtration and washed three times with CH2Cl2 and two times with MeOH. The product was then dried in vacuo to give the title compound 14-4 as a yellow solid. 1H NMR δ 7.37-7.42 (1H, m), 7.47-7.57 (5H, m), 7.73-7.77 (5H, m), 7.95 (2H, t), 8.60 (2H, t); LC-MS: m/e 489(M+H)+.

Provenance & Evidence