5-Chloro-2-nitroaniline → 5-Chloro-4-iodo-2-nitroaniline

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-2-nitroaniline (25 g, 145 mmol) in AcOH (250 mL) was added N-iodosuccinimide (32.6 g 145 mmol). The mixture was stirred overnight at 50° C., cooled down to rt and filtered. The solid residue was washed with AcOH, water, saturated aqueous NaHCO3 and water, and then dried to afford the desired product 16-1 as a brown solid, which was used in the next step without further purification.

Provenance & Evidence