Carbon Disulfide → 5-Chloro-6-iodo-1H-benzo[d]imidazole-2(3H)-thione

HRID 1960146Notes

Reaction equation

HRID 1960146 reaction equation
[OH-].[K+].[C:3](=[S:5])=S.[Cl:6][C:7]1[CH:8]=[C:9]([NH2:15])[C:10]([NH2:14])=[CH:11][C:12]=1[I:13]>O.CCO>[Cl:6][C:7]1[C:12]([I:13])=[CH:11][C:10]2[NH:14][C:3](=[S:5])[NH:15][C:9]=2[CH:8]=1

Participants

6

Reactant 3

HCID 6348Carbon DisulfideHCID 14797Potassium HydroxideHCID 574814674-Chloro-5-iodobenzene-1,2-diamine

Product 1

HCID 574814685-Chloro-6-iodo-1H-benzo[d]imidazole-2(3H)-thione

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

KOH (15.7 g, 238 mmol) in water (50 mL), followed by carbon disulfide (14.4 mL, 238 mmol), was added to a solution of 4-chloro-5-iodobenzene-1,2-diamine 16-2 (50 g, 198 mmol) in EtOH (300 mL). The mixture was heated at reflux for 3 h, cooled and filtered. To the filtrate was added water (300 mL) and then AcOH (25 mL) in water (50 mL). The precipitate was collected, washed with water and a small amount of EtOH and dried to afford the desired product 16-3 as a brown powder, which was used in the next step without further purification.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 3 h
  3. temperaturecooled
  4. filtrationfiltered
  5. additionTo the filtrate was added water (300 mL)
  6. customThe precipitate was collected
  7. washwashed with water
  8. dry with materiala small amount of EtOH and dried

Sources & evidence

ORD record
ord-31bf307e189c477daa984016dcb3033c
Source dataset
uspto-grants-2013_04
Patent number
US08410284B2

Reaction notes

Loading…