Hexamethyldisilazane → HCID 45273893, compound

Participants

Reaction Steps

To a solution of compound 16-8 (70 mg, 0.13 mmol) in 2 mL of CH2Cl2 was added hexamethyldisilizane (0.3 mL), followed by bromo trimethylsilane (0.17 mL, 1.3 mmol). The reaction was allowed to stir for 18 h at ambient temperature. Organic solvent was removed in vacuo, followed by the addition of H2O (2 mL). The crude product was sonicated and yielded a yellow suspension. The product was collected by vacuum filtration and washed three times with CH2Cl2 and two times with MeOH. The resulting solid was dried in vacuo to give the title compound 16-9 as a white solid. 1H NMR δ 3.83 (3H, s), 6.46 (1H, d, J=3 Hz), 7.19 (1H, d, J=8.5 Hz), 7.36 (2H, m), 7.47 (1H, d, J=9 Hz), 7.53-7.63 (6H, m); LC-MS: m/e 454(M+H)+.

Provenance & Evidence